2024/02/06 by Matteo Fornoni, Fornoni, Matteo · 2 citations
Materials Science · #35B65 #35K61 #35Q92 #45K05 #49K20 #92C50 #Analysis of PDEs (math.AP) #FOS: Mathematics #Optimization and Control (math.OC) #Solidification and crystal growth phenomena
paper · pdf · doi:10.48550/arxiv.2402.04204
openalex publication_date 2024/02/06 · openalex created_date 2024/02/08 · openalex updated_date 2026/07/28
We consider a non-local tumour growth model of phase-field type, describing the evolution of tumour cells through proliferation in presence of a nutrient. The model consists of a coupled system, incorporating a non-local Cahn-Hilliard equation for the tumour phase variable and a reaction-diffusion equation for the nutrient. First, we establish novel regularity results for such a model, by applying maximal regularity theory in weighted Lp spaces. This technique enables us to prove the local existence and uniqueness of a regular solution, including also chemotaxis effects. By leveraging time-regularisation properties and global boundedness estimates, we further extend the solution to a global one. These results provide the foundation for addressing an optimal distributed control problem, aimed at identifying a suitable therapy guiding the tumour towards a predefined target. Specifically, we prove the existence of an optimal therapy and, by studying the Fréchet-differentiability of the control-to-state operator and introducing the adjoint system, we derive first-order necessary optimality conditions.