Double‐Stranded RNA Viral Infection ofTrichomonas vaginalisInfecting Patients Attending a Sexually Transmitted Diseases Clinic

2002/08/15 by Karen A. Wendel, Karen A. Wendel, Anne M. Rompalo +7 · 12 citations
Immunology and Microbiology · Medicine · Health Professions · #Reproductive tract infections research #Herpesvirus Infections and Treatments #Pediatric health and respiratory diseases

paper · pdf · doi:10.1086/341832

Abstract

Trichomonas vaginalis (TV) can be infected with double-stranded RNA (dsRNA) viruses that may have important implications for trichomonal virulence and disease pathogenesis. A cross-sectional study was conducted in a sexually transmitted diseases clinic to determine the prevalence and clinical significance of dsRNA viral infection of TV infecting men and women. Overall, dsRNA virus was present in 21 (75%) of 28 TV isolates (95% confidence interval [CI], 55%-89%). dsRNA viral infection of TV was not associated with the presence of discharge, dysuria, genital pruritus, or genital irritation or odor. However, patients with virus-positive isolates were significantly older than patients with virus-negative isolates (median age, 38 vs. 23 years; P=.003), and virus-positive isolates were more prevalent among women (19 [86%] of 22 isolates; 95% CI, 65%-97%) than among men (2 [33%] of 6 isolates; P=.02). The age and sex specificity of virus-positive isolates may aid in understanding the differences in chronicity and clinical presentation of TV in men and women.

Cited by

• Heterogeneity in extracellular nucleotide hydrolysis among clinical isolates of Trichomonas vaginalis. [europepmc]
• Trichomonasvirus: a new genus of protozoan viruses in the family Totiviridae. [europepmc]
• The association between Trichomonas infection and incarceration in HIV-seropositive and at-risk HIV-seronegative women. [europepmc]
• Dientamoeba fragilis, the Neglected Trichomonad of the Human Bowel. [europepmc]
• Trichomonas vaginalis infection in symbiosis with Trichomonasvirus and Mycoplasma. [europepmc]
• Molecular typing of Trichomonas vaginalis isolates by actin gene sequence analysis and carriage of T. vaginalis viruses. [europepmc]
• Trichomonas vaginalis Virus Among Women With Trichomoniasis and Associations With Demographics, Clinical Outcomes, and Metronidazole Resistance. [europepmc]
• Prevalence and Genotyping of Trichomonas vaginalis Infected to dsRNA Virus by PCR-Restriction Fragment Length Polymorphism (RFLP). [europepmc]
• The First Detection of Co-Infection of Double-Stranded RNA Virus 1, 2 and 3 in Iranian Isolates of Trichomonas vaginalis . [europepmc]
• Identification of Endosymbiotic Virus in Small Extracellular Vesicles Derived from Trichomonas vaginalis . [europepmc]
• Microbial Matryoshka: Addressing the Relationship between Pathogenic Flagellated Protozoans and Their RNA Viral Endosymbionts (Family Totiviridae ). [europepmc]
• Trichomonas vaginalis Virus: Current Insights and Emerging Perspectives. [europepmc]

Related

• Systematic review and meta-analysis of the global prevalence and infection risk factors of Trichomonas vaginalis
• Real-time PCRs for detection of Trichomonas vaginalis β-tubulin and 18S rRNA genes in female genital specimens
• Loop mediated isothermal amplification assay for detection of Trichomonas vaginalis in vaginal swabs among symptomatic women from North India
• Impact of bacterial vaginosis on sexually transmitted viral infections: a bacterial point of view
• Diagnostic performance of two molecular assays for the detection of vaginitis in symptomatic women