IL-2 and Related Cytokines Can Promote T Cell Survival by Activating AKT

2002/01/01 by Erin Kelly, Angela Won, A Jin Won +2 · 27 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Immunology and Microbiology · #Cell death mechanisms and regulation #Cytokine Signaling Pathways and Interactions #Immune Cell Function and Interaction

paper · pdf · doi:10.4049/jimmunol.168.2.597

Abstract

The regulated elimination of T cells serves to maintain normal immune function and prevents autoimmune responses. IL-2 family cytokines play an important role in controlling the survival of immature and mature T cells. These molecules activate the protein kinase, AKT/PKB. AKT has been shown to transduce an antiapoptotic signal in numerous cell types. In this study, we show that an active form of AKT can protect T cells from apoptosis following growth factor withdrawal and that IL-2 family cytokines can promote T cell survival by activating this kinase. We also provide evidence that AKT does not block death receptor-mediated killing of lymphocytes. These data suggest that AKT may serve as a common signaling element by which members of the IL-2 family of cytokines promote T cell survival.

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