Leptin in Immunology

2005/03/01 by Giuseppe Matarese, Stergios Moschos, Christos S. Mantzoros +1 · 537 citations
Medicine · Neuroscience · Nursing · #Adipokine #Adipokines, Inflammation, and Metabolic Diseases #Biochemical Analysis and Sensing Techniques #Biology #Cytokine #Endocrinology #Energy homeostasis #Homeostasis #Immune system #Immunology #Inflammation #Internal medicine #Leptin #Medicine #Obesity #Pathophysiology #Proinflammatory cytokine #Regulation of Appetite and Obesity

paper · doi:10.4049/jimmunol.174.6.3137

published in The Journal of Immunology 174(6), 3137-3142 (American Association of Immunologists)

openalex publication_date 2005/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Leptin is an adipokine which conveys information on energy availability. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. As a cytokine, leptin also affects thymic homeostasis and, similar to other proinflammatory cytokines, leptin promotes Th1 cell differentiation and cytokine production. We review herein recent advances on the role of leptin in the pathophysiology of immune responses.

Citations

• Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
• Obesity is associated with macrophage accumulation in adipose tissue

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