Development and validation of a novel immunogenicity assay to detect anti-drug and anti-PEG antibodies simultaneously with high sensitivity

2020/09/09 by Nicoletta Bivi, Craig Swearingen, Craig A. Swearingen +7 · 3 citations
Medicine · Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · #Monoclonal and Polyclonal Antibodies Research #Biosimilars and Bioanalytical Methods #Protein purification and stability

paper · doi:10.1016/j.jim.2020.112856

Citations

• Affinity capture elution bridging assay: A novel immunoassay format for detection of anti-therapeutic protein antibodies

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• Trastuzumab immunogenicity development in patients' sera and in laboratory animals. [europepmc]
• Sensitive assay design for detection of anti-drug antibodies to biotherapeutics that lack an immunoglobulin Fc domain. [europepmc]
• Development of a validated novel bead extraction method for the detection of anti-PEG antibodies in human serum. [europepmc]