2023/11/01 by Xiaojie Yang, Furong Lu · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Atrioventricular cushions #Biology #Cancer-related molecular mechanisms research #Cardiac Valve Diseases and Treatments #Cardiac valve #Cardiology #Congenital heart defects research #Embryonic stem cell #Genetics #Heart development #Heart disease #Heart valve #Internal medicine #Medicine #Mesenchymal stem cell #Mesenchyme #Pathology #Population
paper · open access · doi:10.1369/00221554231207434
published in Journal of Histochemistry & Cytochemistry 71(12), 675-687 (SAGE Publishing)
openalex publication_date 2023/11/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
Heart valve disease is an important cause of morbidity and mortality among cardiac patients worldwide. However, the pathogenesis of heart valve disease is not clear, and a growing body of evidence hints at the importance of the genetic basis and developmental origins of heart valve disease. Therefore, understanding the developmental mechanisms that underlie the formation of heart valves has important implications for the diagnosis, prevention, and treatment of congenital heart disease. Endothelial to mesenchymal transition is a key step in initiating cardiac valve development. The dynamic changes in the relative localization and proportion of different cell sources in the heart valve mesenchymal population are still not fully understood. Here, we used the Cdh5-CreER;R26R-tdTomato mouse line to trace endocardial cushion-derived endothelial cells to explore the dynamic contribution of these cells to each layer of the valve during valve development. This is beneficial for elaborating on the role of endocardial cells in the process of valve remodeling from a precise angle.