GLUT1, LDHA, and MCT4 Expression Is Deregulated in Cervical Cancer and Precursor Lesions

2022/05/26 by Ma. A. Reyna-Hernández, Luz del Carmen Alarcón‐Romero, Luz del C. Alarcón-Romero +10 · 10 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Cancer #Cancer research #Cancer, Hypoxia, and Metabolism #Cancer-related molecular mechanisms research #Cervical Cancer and HPV Research #Cervical cancer #Cervical intraepithelial neoplasia #Epithelium #GLUT1 #Glucose transporter #HPV infection #Immunohistochemistry #Immunostaining #Internal medicine #Lactate dehydrogenase #Lactate dehydrogenase A #Medicine #Pathology

paper · pdf · doi:10.1369/00221554221101662

openalex publication_date 2022/05/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Metabolic reprogramming is typical in cancerous cells and is required for proliferation and cellular survival. In addition, oncoproteins of high-risk human papillomavirus (HR-HPV) are involved in this process. This study evaluated the relationship between glucose transporter I (GLUT1), lactate dehydrogenase A (LDHA), and monocarboxylate transporter type 4 (MCT4) expression and cervical intraepithelial neoplasia (CIN) and invasive cervical carcinoma (ICC) with HR-HPV infection. The protein expression was evaluated in women with CIN I ( n=20), CIN II/III ( n=16), or ICC ( n=24) by immunohistochemistry. The protein expression was analyzed qualitatively by van Zummeren score and quantitatively by Image ProPlus 6 software. LDHA expression increases in HPV-16 infection. In the CIN I group, GLUT1 immunostaining has a 35% protein expression at the membrane level at more than two thirds of the epithelium, which increased by 21.25% more in CIN II/III in more than two thirds of the epithelium. While LDHA and MCT4 in CIN I mostly do not present immunostaining, or this was only limited to the basal stratum, this expression is increased in CIN II/III and ICC cases. The GLUT1, LDHA, and MCT4 expression increased in ICC. The overexpression in high-grade CIN with HR-HPV infection shows a higher risk for cervical carcinoma progression.

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