Deterioro de la integridad cutánea por Pioderma Gangrenoso.

2011/11/21 by Yoshiya Asano, M.P. Hernández Orta, R. Pina García +5 · 20 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Art #Autoimmune Bullous Skin Diseases #Autoimmune and Inflammatory Disorders #Biochemistry #Biology #Cancer research #Cell biology #Chemistry #Cutaneous lymphoproliferative disorders research #Enzyme #Etiology #Ferric #Ferrous #Heme #Heme Oxygenase-1 and Carbon Monoxide #Hemoglobinopathies and Related Disorders #Humanities #Immunohistochemistry #Immunology #Inorganic chemistry #Iron Metabolism and Disorders #Medicine #Oxidative stress #Pathology #Stromal cell

paper · pdf · doi:10.1369/0022155411431734

openalex publication_date 2013/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/06/11

Abstract

Sensitive non-heme iron histochemistry--namely, the perfusion-Perls method and perfusion-Turnbull method--was applied to study the distribution and age-related accumulation of non-heme ferric iron and ferrous iron in mouse ovary. Light and electron microscopic studies revealed that non-heme ferric iron is distributed predominantly in stromal tissue, especially in macrophages. By contrast, the distribution of non-heme ferrous iron was restricted to a few ovoid macrophages. Aged ovaries exhibited remarkable non-heme iron accumulation in all stromal cells. In particular, non-heme ferrous iron level was increased in stromal tissue, suggestive of increased levels of redox-active iron, which can promote oxidative stress. Moreover, intense localization of both non-heme ferric and ferrous iron was observed in aggregated large stromal cells that were then characterized as ceroid-laden enlarged macrophages with frothy cytoplasm. Intraperitoneal iron overload in adult mice resulted in non-heme iron deposition in the entire stroma and generation of enlarged macrophages, suggesting that excessive iron accumulation induced macrophage morphological changes. The data indicated that non-heme iron accumulation in ovarian stromal tissue may be related to aging of the ovary due to increasing oxidative stress.

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