Filamentous influenza viruses

2016/06/30 by Bernadeta Dadonaite, Swetha Vijayakrishnan, Swetha Víjayakríshnan +4 · 108 citations
Medicine · #Biology #Cardiovascular Effects of Exercise #Influenza A virus #Influenza Virus Research Studies #Microbiology #Respiratory viral infections research #Virology #Virus

paper · open access · doi:10.1099/jgv.0.000535

published in Journal of General Virology 97(8), 1755-1764 (Microbiology Society)

openalex publication_date 2016/06/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Clinical isolates of influenza virus produce pleomorphic virus particles, including extremely long filamentous virions. In contrast, strains of influenza that have adapted to laboratory growth typically produce only spherical virions. As a result, the filamentous phenotype has been overlooked in most influenza virus research. Recent advances in imaging and improved animal models have highlighted the distinct structure and functional relevance of filamentous virions. In this review we summarize what is currently known about these strikingly elongated virus particles and discuss their possible roles in clinical infections.

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