Localization of classical swine fever virus in male gonads during subclinical infection

2002/11/01 by Changsun Choi, Chanhee Chae · 6 citations
Agricultural and Biological Sciences · #Animal Disease Management and Epidemiology #Animal Virus Infections Studies #Biology #Classical swine fever #Endocrinology #Epididymis #Gene #Genetics #In situ hybridization #Physiology #Reproductive tract #Sperm #Subclinical infection #Vector-Borne Animal Diseases #Virology #Virus

paper · doi:10.1099/0022-1317-83-11-2717

openalex publication_date 2002/11/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

In an experiment using ten boars, the distribution of classical swine fever virus (CSFV) was determined in the male reproductive tract by in situ hybridization over a period of 120 days after intranasal inoculation. CSFV was detected in the testicular tissue of infected boars. Viral nucleic acid was localized to spermatogonia, spermatocytes and spermatids but was not detected in the epithelia of the prostate, epididymis or bulbourethral gland. Sections from control, CSFV-negative, pigs showed no hybridization signals for CSFV. The demonstration that CSFV infects the spermatogonia (and their progeny) suggests that this may serve as a primary reservoir for the venereal spread of CSFV.

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• In vitro infection with classical swine fever virus inhibits the transcription of immune response genes. [europepmc]
• Detection and localization of atypical porcine pestivirus in the testicles of naturally infected, congenital tremor affected piglets. [europepmc]
• Attachment, Entry, and Intracellular Trafficking of Classical Swine Fever Virus. [europepmc]
• Characterization of Pestivirus scrofae infection in the tissues of a persistently infected boar. [europepmc]

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