2020/07/31 by Naoki Tamemoto, Hiroshi Noguchi · 35 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Physics and Astronomy · #Brusselator #Deformation (meteorology) #Dynamics (music) #Erythrocyte Function and Pathophysiology #Force Microscopy Techniques and Applications #Lipid Membrane Structure and Behavior #Membrane #Non-equilibrium thermodynamics #Oscillation (cell signaling) #Pattern formation #Turing #Vesicle #cond-mat.soft #physics.bio-ph
paper · pdf · doi:10.1038/s41598-020-76695-x
published in Scientific Reports 10(1), 19582 (Nature Portfolio) · 27 pages, 11 figures
openalex created_date 2020/07/29 · arxiv created 2020/11/02 · openalex publication_date 2020/11/11 · arxiv updated 2020/11/19 · openalex updated_date 2026/08/06
Shapes of biological membranes are dynamically regulated in living cells. Although membrane shape deformation by proteins at thermal equilibrium has been extensively studied, nonequilibrium dynamics have been much less explored. Recently, chemical reaction propagation has been experimentally observed in plasma membranes. Thus, it is important to understand how the reaction-diffusion dynamics are modified on deformable curved membranes. Here, we investigated nonequilibrium pattern formation on vesicles induced by mechanochemical feedback between membrane deformation and chemical reactions, using dynamically triangulated membrane simulations combined with the Brusselator model. We found that membrane deformation changes stable patterns relative to those that occur on a non-deformable curved surface, as determined by linear stability analysis. We further found that budding and multi-spindle shapes are induced by Turing patterns, and we also observed the transition from oscillation patterns to stable spot patterns. Our results demonstrate the importance of mechanochemical feedback in pattern formation on deforming membranes.