Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis

2018/01/11 by Donald W. Hilgemann, Gucan Dai, Anthony Collins +4 · 62 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Adapter (computing) #Biochemistry #Biology #Calcium signaling and nucleotide metabolism #Cell biology #Cellular transport and secretion #Chemistry #Computer science #Endocytosis #Lipid Membrane Structure and Behavior #Membrane #Membrane protein #Receptor #Second messenger system #Signal transduction

paper · pdf · doi:10.1085/jgp.201711875

published in The Journal of General Physiology 150(2), 211-224 (Rockefeller University Press)

openalex publication_date 2018/01/11 · openalex created_date 2018/01/26 · openalex updated_date 2026/07/25

Abstract

Lipids influence powerfully the function of ion channels and transporters in two well-documented ways. A few lipids act as bona fide second messengers by binding to specific sites that control channel and transporter gating. Other lipids act nonspecifically by modifying the physical environment of channels and transporters, in particular the protein–membrane interface. In this short review, we first consider lipid signaling from this traditional viewpoint, highlighting innumerable Journal of General Physiology publications that have contributed to our present understanding. We then switch to our own emerging view that much important lipid signaling occurs via the formation of membrane domains that influence the function of channels and transporters within them, promote selected protein–protein interactions, and control the turnover of surface membrane.

Citations

• Synergistic Activation of G Protein–Gated Inwardly Rectifying Potassium Channels by the βγ Subunits of G Proteins and Na+ and Mg2+ Ions
• Regulation of voltage-gated potassium channels by PI(4,5)P2

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