THE METABOLISM OF TUMORS IN THE BODY
1927/03/07 by Otto Warburg, Otto Warbürg, Franz Wind +1 · 4,394 citations
Chemistry · Medicine · #Biochemistry #Chemistry #Metabolism #Neuroblastoma Research and Treatments
paper · pdf · doi:10.1085/jgp.8.6.519
published in The Journal of General Physiology 8(6), 519-530 (Rockefeller University Press)
openalex publication_date 1927/03/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Abstract
In this contribution we discuss the question of whether tumor cells in living animals can be killed off through lack of energy, and the related question of how the tumors are supplied with oxygen and glucose in the body.
Cited by
- Mitochondrial metabolism as a pharmacological target for cancer therapeutics
- Orchestrating glucose metabolism: PFKFB2 as a signal-integrating conductor in homeostasis and disease
- Discovery ofFirst-in-Class Carbonic Anhydrase/HistoneDeacetylase Dual Inhibitors with Antiproliferative Activity in CancerCells
- The Warburg effect: 80 years on
- Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy
- Targeting succinylation-mediated metabolic reprogramming as a potential approach for cancer therapy
- Successful application of dietary ketogenic metabolic therapy in patients with glioblastoma: a clinical study
- Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype
- Thermal resonance in cancer
- The multifaceted roles of mitochondria at the crossroads of cell life and death in cancer
- Metabolic reprogramming in macrophages and dendritic cells in innate immunity
- Design, synthesis and biological evaluation of naphthalene-1,4-dione analogues as anticancer agents
- Porphyromonas gingivalis ‐Lipopolysaccharide Induced Gingival Fibroblasts Trained Immunity Sustains Inflammation in Periodontitis
- The role of GAPDH in the selective toxicity of CNP in melanoma cells
- Spatial heterogeneity of lactylation: insights into gene expression, metabolism, and lactate transport in human embryonic stem cells
- Bi-Polar Bioenergetic Intervention via a Pathology Self-Adaptive Single-Atom Nanocatalyst for Diabetic Tumor Postoperative Management
- Coupling of ATP and PMF in Escherichia coli is determined by growth conditions
- The role of fibroblast growth factors in cell and cancer metabolism
- Development and Validation of a Carbohydrate Metabolism-Related Model for Predicting Prognosis and Immune Landscape in Hepatocellular Carcinoma Patients
- The hallmarks of cancer metabolism: Still emerging
- Metabolic reprogramming in macrophage responses
- tRNA-derived fragment tRFLys-CTT-010 promotes triple-negative breast cancer progression by regulating glucose metabolism via G6PC
- The Warburg effect: The hacked mitochondrial-nuclear communication in cancer
- Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease
- Brain development and bioenergetic changes
- Deep learning framework integrating 18F-FDG PET/CT and clinical data for early prediction of chemotherapy response in advanced breast cancer
- Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer
- Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification
- Glutamine addiction: a new therapeutic target in cancer
- O-GlcNAcylation: key regulator of glycolytic pathways
- Deciphering the Metabolic Basis and Molecular Circuitry of the Warburg Paradox in Lymphoma
- Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question
- Regulation of gene expression by glycolytic and gluconeogenic enzymes
- Restricted Calorie Ketogenic Diet for the Treatment of Glioblastoma Multiforme
- Glucose metabolism in cancer cells
- Lactate-Protected Hypoglycemia (LPH)
- ATP synthesis and storage
- TP53 mutation hits energy metabolism and increases glycolysis in breast cancer
- Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX
- In silicoestimates of the free energy rates in growing tumor spheroids
- Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism
- Lactate and Acidity in the Cancer Microenvironment
- Biographical Sketch: Otto Heinrich Warburg, PhD, MD
- Metabolic Regulation of Mammalian Stem Cell Differentiation
- Microfluidics [wikipedia]
- Glutamine addiction: a new therapeutic target in cancer. [europepmc]
- Cancer cell metabolism: one hallmark, many faces. [europepmc]
- Human mitochondrial DNA: roles of inherited and somatic mutations. [europepmc]
- The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. [europepmc]
- Tackling the cancer stem cells - what challenges do they pose? [europepmc]
- Metabolic reprogramming: the emerging concept and associated therapeutic strategies. [europepmc]
- The Emerging Hallmarks of Cancer Metabolism. [europepmc]
- The Warburg Effect: How Does it Benefit Cancer Cells? [europepmc]
- Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. [europepmc]
- HIF1α and metabolic reprogramming in inflammation. [europepmc]
- Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? [europepmc]
- Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies. [europepmc]
- Lactate Metabolism in Human Lung Tumors. [europepmc]
- Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. [europepmc]
- Colonocyte metabolism shapes the gut microbiota. [europepmc]
- Metabolic regulation of cell growth and proliferation. [europepmc]
- The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism. [europepmc]
- Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches. [europepmc]
- Amino acids in cancer. [europepmc]
- Lactate as a fulcrum of metabolism. [europepmc]
- Lactate: the ugly duckling of energy metabolism. [europepmc]
- The updated landscape of tumor microenvironment and drug repurposing. [europepmc]
- Metabolic reprogramming in macrophage responses. [europepmc]
- The hallmarks of cancer metabolism: Still emerging. [europepmc]
- Targeting p53 pathways: mechanisms, structures, and advances in therapy. [europepmc]
Related