2020/01/31 by Marinho A. Lopes, Jiaxiang Zhang, Dominik Krzemiński +4 · 1 citation
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #q-bio.NC #cond-mat.dis-nn
paper · pdf · doi:10.1111/ejn.14960
77 pages, 11 figures; note: the acknowledgments section is the most complete in this arxiv version (compared to the published version in EJN)
arxiv created 2020/09/16 · arxiv updated 2020/09/17
Evidence suggests that brain network dynamics is a key determinant of brain function and dysfunction. Here we propose a new framework to assess the dynamics of brain networks based on recurrence analysis. Our framework uses recurrence plots and recurrence quantification analysis to characterize dynamic networks. For resting-state magnetoencephalographic dynamic functional networks (dFNs), we have found that functional networks recur more quickly in people with epilepsy than healthy controls. This suggests that recurrence of dFNs may be used as a biomarker of epilepsy. For stereo electroencephalography data, we have found that dFNs involved in epileptic seizures emerge before seizure onset, and recurrence analysis allows us to detect seizures. We further observe distinct dFNs before and after seizures, which may inform neurostimulation strategies to prevent seizures. Our framework can also be used for understanding dFNs in healthy brain function and in other neurological disorders besides epilepsy.