2023/06/29 by Roßbach, Bernd, Letzel, Stephan, Drexler, Hans +2
#Arbeitsstoff #Arsen #Arsenic #BLW #Biologischer Leitwert #Biomonitoring #EKA #Expositionsäquivalente für krebserzeugende Arbeitsstoffe #Gefahrstoff #Toxizität #Urin #anorganische Arsenverbindungen #biological guidance value #biomonitoring #exposure equivalents for carcinogenic substances #hazardous substance #inorganic arsenic compounds #occupational exposure #toxicity #urine
paper · doi:10.34865/bb744038e8_2ad
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area re-evaluated the exposure equivalents for carcinogenic substances (EKA) as well as the biological guidance value (BLW) for arsenic [7440-38-2] and inorganic arsenic compounds with the exception of arsine. Recent findings on formation and renal excretion of the arsenic metabolite dimethylarsinic acid suggest substantial alimentary influence on this parameter, which has been used as biomarker besides other metabolites. In order to increase the diagnostic reliability, EKA were derived without the use of dimethylarsinic acid as marker for internal exposure, taking into account now the metabolites arsenic(III), arsenic(V) and monomethylarsonic acid. Furthermore, the range of the EKA was extended to concentrations below 1 µg/m3. Analogous to the EKA derivation, the BLW was re-evaluated based on the renal excretion of the species arsenic(III), arsenic(V) and monomethylarsonic acid. To prevent peripheral neuropathy as the most critical systemic toxic effect besides carcinogenicity, an average concentration of 10 µg/l for the sum of arsenic(III), arsenic(V) and monomethylarsonic acid should not be exceeded in post shift urine samples.