2019/06/30 by Sanjukta Krishnagopal, Rainer Von Coelln, Rainer von Coelln +2 · 35 citations
Mathematics · Medicine · Physics and Astronomy · #Artificial intelligence #Bioinformatics #Biology #Bipartite graph #Cluster analysis #Computational biology #Computer science #Disease #Identification (biology) #Internal medicine #Medicine #Parkinson's Disease Mechanisms and Treatments #Theoretical computer science #Trajectory #math.DS #physics.bio-ph #physics.data-an #stat.AP
paper · pdf · doi:10.1371/journal.pone.0233296
published in PLoS ONE 15(6), e0233296 (Public Library of Science) · 14 pages, 4 figures
arxiv created 2019/07/07 · openalex publication_date 2020/06/17 · arxiv updated 2020/07/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06
Chronic medical conditions show substantial heterogeneity in their clinical features and progression. We develop the novel data-driven, network-based Trajectory Profile Clustering (TPC) algorithm for 1) identification of disease subtypes and 2) early prediction of subtype/disease progression patterns. TPC is an easily generalizable method that identifies subtypes by clustering patients with similar disease trajectory profiles, based not only on Parkinson's Disease (PD) variable severity, but also on their complex patterns of evolution. TPC is derived from bipartite networks that connect patients to disease variables. Applying our TPC algorithm to a PD clinical dataset, we identify 3 distinct subtypes/patient clusters, each with a characteristic progression profile. We show that TPC predicts the patient's disease subtype 4 years in advance with 72% accuracy for a longitudinal test cohort. Furthermore, we demonstrate that other types of data such as genetic data can be integrated seamlessly in the TPC algorithm. In summary, using PD as an example, we present an effective method for subtype identification in multidimensional longitudinal datasets, and early prediction of subtypes in individual patients.