2020/12/11 by Fengrun Sun, Songcun Wang, Meirong Du · 1 citation
Immunology and Microbiology · Medicine · #Biology #Cancer research #Decidua #Decidual cells #Fetus #Immune system #Immune tolerance #Immunology #In vitro #Macrophage #Miscarriage #Placenta #Preeclampsia #Pregnancy #Pregnancy and Medication Impact #Pregnancy and preeclampsia studies #Reproductive System and Pregnancy #Spiral artery #Stromal cell #Trophoblast
paper · pdf · doi:10.1016/j.jri.2020.103264
openalex publication_date 2020/12/11 · crossref created 2020/12/11 · crossref issued 2021/02/01 · crossref published 2021/02/01 · crossref published-print 2021/02/01 · crossref deposited 2025/09/28 · openalex created_date 2025/10/10 · crossref indexed 2026/08/05 · openalex updated_date 2026/08/06
A successful pregnancy requires that the maternal immune system recognizes and tolerates the semi-allogeneic fetus without compromising the capability of protecting both mother and fetus from various pathogens. Decidual macrophages present unique phenotypes to play a key role in the establishment of the immunological aspects of maternal-fetal interaction. Dysfunction of decidual macrophages gives rise to pregnancy complications such as preeclampsia, recurrent spontaneous miscarriage, preterm labor and fetal growth restriction. Here, we reviewed the latest knowledge on the origin, differentiation, unique phenotype and function of macrophages in normal pregnancy and in pregnancy complications. We mainly focused on the significant roles of decidual macrophages in the process of extravillous trophoblast invasion, spiral arterial remodeling, decidual stromal cells cultivation and immune tolerance maintenance in normal pregnancy, and their pathological roles in pregnancy-related complications, offering more integrated information in maternal-fetal immunity.