Psychometric and Genetic Architecture of Substance Use Disorder and Behavioral Disinhibition Measures for Gene Association Studies

2010/12/11 by Brian M. Hicks, Benjamin D. Schalet, Stephen M. Malone +2 · 113 citations
Medicine · Psychology · #Behavioral Health and Interventions #Behavioural genetics #Biology #Clinical psychology #Cognitive Abilities and Testing #Developmental psychology #Disinhibition #Gene #Genetic architecture #Genetic association #Genetics #Genome-wide association study #Health psychology #Heritability #Medicine #Psychiatry #Psychology #Public health #Quantitative trait locus #Single-nucleotide polymorphism #Substance Abuse Treatment and Outcomes #Substance abuse #Twin study

paper · open access · doi:10.1007/s10519-010-9417-2

published in Behavior Genetics 41(4), 459-475 (Springer Science+Business Media)

openalex publication_date 2010/12/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Citations

• P300 amplitude, externalizing psychopathology, and earlier- versus later-onset substance-use disorder.
• Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
• Prevalence, Correlates, Disability, and Comorbidity of DSM-IV Drug Abuse and Dependence in the United States

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• Testing Causal Effects of Maternal Smoking During Pregnancy on Offspring’s Externalizing and Internalizing Behavior
• A Genome-Wide Association Study of Behavioral Disinhibition
• Molecular genetic approaches to understanding the comorbidity of psychiatric disorders
• The co-occurring use and misuse of cannabis and tobacco: a review. [europepmc]
• Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world. [europepmc]
• Three mutually informative ways to understand the genetic relationships among behavioral disinhibition, alcohol use, drug use, nicotine use/dependence, and their co-occurrence: twin biometry, GCTA, and genome-wide scoring. [europepmc]
• A genome-wide association study of behavioral disinhibition. [europepmc]
• Genetic and environmental influences on the familial transmission of externalizing disorders in adoptive and twin offspring. [europepmc]
• Rare nonsynonymous exonic variants in addiction and behavioral disinhibition. [europepmc]
• Identifying childhood characteristics that underlie premorbid risk for substance use disorders: socialization and boldness. [europepmc]
• Cannabis controversies: how genetics can inform the study of comorbidity. [europepmc]
• Adolescent drinking and motivated decision-making: a cotwin-control investigation with monozygotic twins. [europepmc]
• Attention-deficit/hyperactivity disorder subtypes and substance use and use disorders in NESARC. [europepmc]
• Predictive validity of delay discounting behavior in adolescence: a longitudinal twin study. [europepmc]
• The Genetics, Neurogenetics and Pharmacogenetics of Addiction. [europepmc]
• Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. [europepmc]
• Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample. [europepmc]
• The role of conduct disorder in the relationship between alcohol, nicotine and cannabis use disorders. [europepmc]
• Testing Causal Effects of Maternal Smoking During Pregnancy on Offspring's Externalizing and Internalizing Behavior. [europepmc]
• Changing relationships between smoking and psychiatric disorders across twentieth century birth cohorts: clinical and research implications. [europepmc]
• Genetic and Environmental Influences on Parent-Child Conflict and Child Depression Through Late Adolescence. [europepmc]
• Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict. [europepmc]
• Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics. [europepmc]
• Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. [europepmc]
• Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use. [europepmc]
• Parenting and prenatal risk as moderators of genetic influences on conduct problems during middle childhood. [europepmc]
• Redefining phenotypes to advance psychiatric genetics: Implications from hierarchical taxonomy of psychopathology. [europepmc]
• Digital media use and subsequent cannabis and tobacco product use initiation among adolescents. [europepmc]