2024/03/22 by Chen, Zhuo, Kao, Chien-Min, Huang, Hsin-Hsiung +1
#FOS: Physical sciences #Medical Physics (physics.med-ph)
paper · doi:10.48550/arxiv.2403.14994
Positron Emission Tomography (PET) is a crucial tool in medical imaging, particularly for diagnosing diseases like cancer and Alzheimer's. The advent of Positronium Lifetime Imaging (PLI) has opened new avenues for assessing the tissue micro-environment, which is vital for early-stage disease detection. In this study, we introduce a two-component reconstruction model for PLI in Time-of-Flight (TOF) PET, incorporating both ortho-positronium and para-positronium decays. Our model enhances the accuracy of positronium imaging by providing a more detailed representation of the tissue environment. We conducted simulation studies to evaluate the performance of our model and compared it with existing single-component models. The results demonstrate the superiority of the two-component model in capturing the intricacies of the tissue micro-environment, thus paving the way for more precise and informative PET diagnostics.