2017/03/03 by Simona Cocco, Christoph Feinauer, Matteo Figliuzzi +2 · 4 citations
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #q-bio.BM #cond-mat.stat-mech #q-bio.QM
paper · pdf · doi:10.1088/1361-6633/aa9965
published as Rep. Prog. Phys. 81, 032601 (2018) · 18 pages, 7 figures
arxiv created 2017/03/03 · arxiv updated 2019/10/07
In the course of evolution, proteins undergo important changes in their amino acid sequences, while their three-dimensional folded structure and their biological function remain remarkably conserved. Thanks to modern sequencing techniques, sequence data accumulate at unprecedented pace. This provides large sets of so-called homologous, i.e.~evolutionarily related protein sequences, to which methods of inverse statistical physics can be applied. Using sequence data as the basis for the inference of Boltzmann distributions from samples of microscopic configurations or observables, it is possible to extract information about evolutionary constraints and thus protein function and structure. Here we give an overview over some biologically important questions, and how statistical-mechanics inspired modeling approaches can help to answer them. Finally, we discuss some open questions, which we expect to be addressed over the next years.