Dynein catch bond as a mediator of codependent bidirectional cellular transport

2018/01/31 by Palka Puri, Nisha Gupta, Sameep Chandel +5 · 16 citations
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Dynein #Intracellular #Mechanism (biology) #Mediator #Micro and Nano Robotics #Microtubule and mitosis dynamics #Motility #Motor protein #Nuclear Structure and Function #physics.bio-ph #q-bio.SC

paper · pdf · doi:10.1103/physrevresearch.1.023019

published in Physical Review Research 1(2) (American Physical Society) · 14 pages, 13 figures

openalex created_date 2018/02/02 · arxiv created 2019/08/13 · openalex publication_date 2019/09/18 · arxiv updated 2019/09/25 · openalex updated_date 2026/08/05

Abstract

The authors show the existence of an internal regulatory mechanism for intracellular cargo transport arising from the unique ``catchbond'' behavior of dynein motors which can in turn give rise to coordinated transport. This appears to resolve the observed paradox by which inhibiting the activity of one type of motor results in an overall decline in the motility of the cellular cargo in both directions.

Citations

• A general method for numerically simulating the stochastic time evolution of coupled chemical reactions
• Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors