2001/06/13 by Hiroshi Kadotani · 2 citations
Medicine · Psychology · #Obstructive Sleep Apnea Research #Sleep and related disorders #Dementia and Cognitive Impairment Research #Medicine #Polysomnography #Apolipoprotein E #Internal medicine #Population #Sleep apnea #Apnea–hypopnea index #Body mass index #Cardiology #Disease #Apnea
paper · doi:10.1001/jama.285.22.2888
openalex publication_date 2001/06/13 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
CONTEXT: Apolipoprotein E epsilon4(ApoE epsilon4) is a well-known risk factor for Alzheimer disease and cardiovascular disease. Sleep-disordered breathing occurs in Alzheimer disease patients and increases risks for cardiovascular disease. Complex interactions among sleep, brain pathology, and cardiovascular disease may occur in ApoE epsilon4 carriers. OBJECTIVE: To study whether genetic variation at the level of ApoE is associated with sleep-disordered breathing or sleep abnormalities in the general population. DESIGN, SETTING, AND PARTICIPANTS: Ongoing longitudinal cohort study of sleep disorders at a US university beginning in 1989, providing a population-based probability sample of 791 middle-aged adults (mean [SD] age, 49 [8] years; range, 32-68 years). MAIN OUTCOME MEASURE: Nocturnal polysomnography to evaluate apnea-hypopnea index. RESULTS: The probability of moderate-to-severe sleep-disordered breathing (apnea-hypopnea index >/=15%) was significantly higher in participants with epsilon4, independent of age, sex, body mass index, and ethnicity (12.0% vs 7.0%; P =.003). Mean (SEM) apnea-hypopnea index was also significantly higher in participants with ApoE epsilon4 (6.5 [0.6] vs 4.8 [0.3]; P =.01). These effects increased with the number of ApoE epsilon4 alleles carried. CONCLUSIONS: A significant portion of sleep-disordered breathing is associated with ApoE epsilon4 in the general population.