Transforming growth factor–β in tissue fibrosis
2020/02/20 by Nikolaos G. Frangogiannis · 1,282 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Connective Tissue Growth Factor Research #Fibrosis #Growth factor #Internal medicine #Medicine #Pathology #Systemic Sclerosis and Related Diseases #TGF-β signaling in diseases #Transforming growth factor
paper · pdf · doi:10.1084/jem.20190103
published in The Journal of Experimental Medicine 217(3), e20190103 (Rockefeller University Press)
openalex publication_date 2020/02/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/03
Abstract
TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-β from latent stores requires the cooperation of proteases, integrins, and specialized extracellular matrix molecules. Although fibroblasts are major targets of TGF-β, some fibrogenic actions may reflect activation of other cell types, including macrophages, epithelial cells, and vascular cells. TGF-β-driven fibrosis is mediated through Smad-dependent or non-Smad pathways and is modulated by coreceptors and by interacting networks. This review discusses the role of TGF-β in fibrosis, highlighting mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic translation.
Citations
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