Lymphatic transport in anti-tumor immunity and metastasis

2025/02/19 by Mengzhu Sun, Julien Angelillo, Stéphanie Hugues · 1 voice · 9 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Lymphatic System and Diseases #Angiogenesis and VEGF in Cancer #Vascular Malformations and Hemangiomas

paper · doi:10.1084/jem.20231954

Abstract

Although lymphatic vessels (LVs) are present in many tumors, their importance in cancer has long been underestimated. In contrast to the well-studied tumor-associated blood vessels, LVs were previously considered to function as passive conduits for tumor metastasis. However, emerging evidence over the last two decades has shed light on their critical role in locally shaping the tumor microenvironment (TME). Here we review the involvement of LVs in tumor progression, metastasis, and modulation of anti-tumor immune response.

Citations

• DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling
• Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation
• Lymph node stromal cells acquire peptide–MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance
• A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
• Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
• Inflammation-associated lymphangiogenesis: a double-edged sword?
• Functionally specialized junctions between endothelial cells of lymphatic vessels
• An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
• Lymphatic vessels regulate immune microenvironments in human and murine melanoma
• Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation
• Infection-induced lymphatic zippering restricts fluid transport and viral dissemination from skin

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• Lymphatics-on-a-chip microphysiological system: engineering lymphatic structure and function in vitro . [europepmc]
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• Targeting angiogenesis: Lessons from 25 years of normalizing tumor vasculature. [europepmc]

Discussions

• Review @jem.org Lymphatic transport in anti-tumor immunity and metastasis doi.org/10.1084/jem.... [bsky, 5 points, 0 comments]

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