1972/03/01 by Thomas Gottlieb, Fred H. Katz, Charles A. Chidsey · 1 citation
Medicine · Nursing · #Blood Pressure and Hypertension Studies #Hormonal Regulation and Hypertension #Sodium Intake and Health #Hydralazine #Minoxidil #Medicine #Hydrochlorothiazide #Propranolol #Blood pressure #Thiazide #Pindolol #Vasodilation #Blockade #Pharmacology #Plasma renin activity #Antihypertensive drug #Essential hypertension #Internal medicine #Renin–angiotensin system
paper · pdf · doi:10.1161/01.cir.45.3.571
openalex publication_date 1972/03/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/22
The hypotensive efficacies of two vasodilators, hydralazine and minoxidil, were assessed as these drugs were used individually in combination with beta-adrenergic blockade and diuretics in 11 hypertensive patients in whom elevated blood pressure had not been adequately controlled previously by other antihypertensive therapy. Control supine blood pressure fell from 191/128 mm Hg on propranolol and hydrochlorothiazide to 169/108 mm Hg on hydralazine, with a significantly greater reduction to 142/92 mm Hg on minoxidil. Although sodium retention and tachycardia were controlled by the use of concomitant diuretics and beta-blockade, an increment in each of these drugs was occasionally required to prevent these complications. Renal function was changed little with the decrease in blood pressure. Plasma renin increased from a standing control of 14.5 mµg/ml/hr to 35.9 and 31.1 mµg/ml/hr, respectively, on hydralazine and minoxidil. These data suggest the role of vasodilators used in combination with beta-blockers and diuretics and indicate the greater therapeutic efficacy of minoxidil.