1984/08/24 by Jay A. Levy, Anthony Hoffman, Susan M. Kramer +3 · 1 citation
Immunology and Microbiology · Medicine · #T-cell and Retrovirus Studies #Viral-associated cancers and disorders #Immunodeficiency and Autoimmune Disorders #Virology #Retrovirus #Antibody #Reverse transcriptase #Cytopathic effect #Antiserum #Medicine #Human immunodeficiency virus (HIV) #Immunology #Immune system #Biology #Virus #Genetics #RNA
paper · doi:10.1126/science.6206563
openalex publication_date 1984/08/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
Infectious retroviruses have been detected in 22 of 45 randomly selected patients with acquired immune deficiency syndrome (AIDS) and in other individuals from San Francisco. The AIDS-associated retroviruses (ARV) studied in detail had a type D morphology, Mg2+-dependent reverse transcriptase, and cytopathic effects on lymphocytes. The viruses can be propagated in an established adult human T cell line, HUT-78. They cross-react with antiserum to the lymphadenopathy-associated retrovirus isolated from AIDS patients in France. Antibodies to ARV were found in all 86 AIDS patients and in a high percentage of 88 other homosexual men in San Francisco. This observation indicates the widespread presence of these lymphocytopathic retroviruses and their close association with AIDS.