2012/05/04 by Qin Yu, Tobias M. Schneider, Michael P. Brenner · 8 citations
Engineering · Biochemistry, Genetics and Molecular Biology · #Innovative Microfluidic and Catalytic Techniques Innovation #Genomics and Phylogenetic Studies #Glycosylation and Glycoproteins Research #Computational biology #Biology #Evolutionary biology
paper · pdf · doi:10.1371/journal.pone.0035819
published in PLoS ONE 7(5), e35819 (Public Library of Science)
openalex publication_date 2012/05/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Sequencing by Hybridization (SBH) reconstructs an n-long target DNA sequence from its biochemically determined l-long subsequences. In the standard approach, the length of a uniformly random sequence that can be unambiguously reconstructed is limited to n = O(2(l)) due to repetitive subsequences causing reconstruction degeneracies. We present a modified sequencing method that overcomes this limitation without the need for different types of biochemical assays and is robust to error.