Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs

2017/07/07 by Bridgett M. vonHoldt, Emily G. Shuldiner, Ilana J. Koch +9 · 2 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Biology #Computer science #Congenital heart defects research #Domestication #Evolutionary biology #Gene #Genetics #Phenotype #Selection (genetic algorithm) #Williams Syndrome Research

paper · pdf · doi:10.1126/sciadv.1700398

openalex publication_date 2017/07/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22

Abstract

, genes previously implicated in the behavioral phenotype of patients with WBS and contained within the WBS locus, contribute to extreme sociability in dogs. This finding suggests that there are commonalities in the genetic architecture of WBS and canine tameness and that directional selection may have targeted a unique set of linked behavioral genes of large phenotypic effect, allowing for rapid behavioral divergence of dogs and wolves, facilitating coexistence with humans.

Citations

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• Biology’s best friend: Bridging disciplinary gaps to advance canine science
• Dog [wikipedia]

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