2019/01/09 by Thomas Kirchner, Janek Gröhl, Kirchner, Thomas +11
Engineering · Medicine · #FOS: Physical sciences #Medical Physics (physics.med-ph) #Photoacoustic and Ultrasonic Imaging #Thermal Regulation in Medicine #Ultrasound and Hyperthermia Applications
paper · pdf · doi:10.48550/arxiv.1901.02786
openalex publication_date 2019/01/09 · openalex created_date 2022/07/30 · openalex updated_date 2026/07/28
Spreading depolarization (SD) is a self-propagating wave of near-complete\nneuronal depolarization that is abundant in a wide range of neurological\nconditions, including stroke. SD was only recently documented in humans and is\nnow considered a therapeutic target for brain injury, but the mechanisms\nrelated to SD in complex brains are not well understood. While there are\nnumerous approaches to interventional imaging of SD on the exposed brain\nsurface, measuring SD deep in brain is so far only possible with low\nspatiotemporal resolution and poor contrast. Here, we show that photoacoustic\nimaging enables the study of SD and its hemodynamics deep in the gyrencephalic\nbrain with high spatiotemporal resolution. As rapid neuronal depolarization\ncauses tissue hypoxia, we achieve this by continuously estimating blood\noxygenation with an intraoperative hybrid photoacoustic and ultrasonic (PAUS)\nimaging system. Due to its high resolution, promising imaging depth and high\ncontrast, this novel approach to SD imaging can yield new insights into SD and\nthereby lead to advances in stroke, and brain injury research.\n