2017/08/15 by Hiroshi Ashikaga, Ameneh Asgari-Targhi · 1 citation
Biochemistry, Genetics and Molecular Biology · #q-bio.QM #q-bio.TO
published as Sci Rep 8: 1967, 2018 · 20 pages, 8 figures
arxiv created 2017/08/15 · arxiv updated 2018/02/02
To prevent sudden cardiac death, predicting where in the cardiac system an order-disorder phase transition into ventricular fibrillation begins is as important as when it begins. We present a computationally efficient, information-theoretic approach to predicting the locations of wavebreaks that initiate fibrillation in a cardiac system where the order-disorder behavior is controlled by a single driving component, mimicking electrical misfiring from the pulmonary veins or the Purkinje fibers. Communication analysis between the driving component and each component of the system reveals that channel capacity, mutual information and transfer entropy can locate the wavebreaks. This approach is applicable to interventional therapies to prevent sudden death, as well as to a wide range of systems to mitigate or prevent imminent phase transitions.