2010/08/30 by Mette K. Andersen, Virve Lundgren, Joni A. Turunen +5 · 88 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Diabetes and associated disorders #T-cell and B-cell Immunology #Pancreatic function and diabetes #Medicine #PTPN22 #Type 1 diabetes #Internal medicine #Diabetes mellitus #Type 2 diabetes #Endocrinology #Quartile #Genotype #Autoimmune diabetes #Human leukocyte antigen #Single-nucleotide polymorphism #Immunology #Genetics #Antigen #Biology #Gene #Confidence interval
paper · pdf · doi:10.2337/dc09-2188
published in Diabetes Care 33(9), 2062-2064 (American Diabetes Association)
openalex publication_date 2010/08/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
OBJECTIVE: We studied differences between patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes, and classical type 1 diabetes diagnosed after age 35 years. RESEARCH DESIGN AND METHODS: Polymorphisms in HLA-DQB1, INS, PTPN22, and CTLA4 were genotyped in patients with LADA (n = 213), type 1 diabetes diagnosed at >35 years of age (T1D(>35y); n = 257) or <20 years of age (T1D(<20y); n = 158), and type 2 diabetes. RESULTS: Although patients with LADA had an increased frequency of HLA-DQB1 and PTPN22 risk genotypes and alleles compared with type 2 diabetic subjects, the frequency was significantly lower compared with T1D(>35y) patients. Genotype frequencies, measures of insulin secretion, and metabolic traits within LADA differed according to GAD antibody (GADA) quartiles, but even the highest quartile differed from type 1 diabetes. Having two or more risk genotypes was associated with lower C-peptide concentrations in LADA. CONCLUSIONS: LADA patients differed genetically and phenotypically from both T1D(>35y) and type 2 diabetic patients in a manner dependent on GADA levels.