2003/11/01 by Silvia Paracchini, C L Pearce, L N Kolonel +3 · 30 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities #Prostate Cancer Diagnosis and Treatment #Forensic and Genetic Research #Prostate cancer #Odds ratio #Oncology #Prostate #Cancer #Cohort #Biology #Internal medicine #Risk factor #Confidence interval #Gynecology #Genetics #Medicine
paper · pdf · doi:10.1136/jmg.40.11.815
published in Journal of Medical Genetics 40(11), 815-819 (BMJ)
openalex publication_date 2003/11/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
BACKGROUND: A Y chromosomal role in prostate cancer has previously been suggested by both cytogenetic findings and patterns of Y chromosomal gene expression. We took advantage of the well established and stable phylogeny of the non-recombining segment of the Y chromosome to investigate the association between Y chromosomal DNA variation and prostate cancer risk. METHODS: We examined the distribution of 116 Y lineages in 930 prostate cancer cases and 1208 controls from four ethnic groups from a cohort study in Hawaii and California. RESULTS: One lineage, found only among the Japanese group in our study, was associated with a statistically significant predisposition to prostate cancer (odds ratio (OR) = 1.63; 95% confidence interval (CI) 1.07 to 2.47), and, in particular, to high severity disease in younger individuals (OR = 3.89; 95% CI 1.34 to 11.31). CONCLUSIONS: This finding suggests that a Y chromosomal factor contributes significantly to the development of prostate cancer in Japanese men.