2005/01/11 by Akira Yanagisawa, Taichiro Touge, Takayoshi Arai · 1 citation
Chemistry · #Asymmetric Synthesis and Catalysis #Asymmetric Hydrogenation and Catalysis #Synthetic Organic Chemistry Methods #Enantioselective synthesis #Protonation #Chemistry #Silylation #Catalysis #Dichloromethane #Trimethylsilyl #BINAP #Fluoride #Methanol #Organic chemistry #Medicinal chemistry #Inorganic chemistry #Solvent
paper · doi:10.1002/anie.200462325
openalex publication_date 2005/01/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26
Silver lining: A catalytic enantioselective protonation of trimethylsilyl enolates uses a binap/silver(I) fluoride complex as a chiral catalyst in a mixture of dichloromethane and methanol (see scheme). Various ketones with tertiary asymmetric carbon centers at the α position can be prepared with high enantioselectivities.