2017/04/07 by M. W. C. Dharma-wardana
Biochemistry, Genetics and Molecular Biology · Environmental Science · Physics and Astronomy · #Arsenic contamination and mitigation #Calcium #Context (archaeology) #Electrochemistry #Etiology #Fluoride #Fluoride Effects and Removal #Heavy Metal Exposure and Toxicity #Kidney disease #Magnesium #Metalloid #Micronutrient #cond-mat.soft #q-bio.TO
paper · pdf · doi:10.1007/s10653-017-0017-4
published as Environmental Geochemistry and Health 1st September (2017) · 14 pages, one figure
arxiv created 2017/04/07 · openalex created_date 2017/05/05 · openalex publication_date 2017/09/01 · arxiv updated 2017/12/15 · openalex updated_date 2026/08/05
Recent experimental work on the nephrotoxicity of contaminants in drinking water using laboratory mice, motivated by the need to understand the origin of chronic kidney disease of unknown aetiology is examined within our understanding of the hydration of ions and proteins. Qualitative considerations based on Hofmeister-type action of these ions, as well as quantitative electrochemical models for the Gibbs free-energy change for ion-pair formation are used to explain why Cd2+ in the presence of F- and water hardness due to Mg2+ ions (but not Ca2+) can be expected to be more nephrotoxic, while AsO33- in the presence of F- and hardness may be expected to be less nephrotoxic. The analysis is applied to a variety of ionic species typically found in water to predict their likely combined electro-chemical action. These results clarify the origins of chronic kidney disease in the north-central province of Sri Lanka. The conclusion is further strengthened by a study of the dietary load of Cd and As, where the dietary loads are found to be safe, especially when the mitigating effects of micronutrient ionic forms of Zn and Se, as well as corrections for bio-availability are taken in to account. The resulting aetiological picture supports the views that F-, Cd2+ (to a lesser extent), and Mg2+ ions found in stagnant household well water act together with enhanced toxicity, becoming the most likely causative factor of the disease. Similar incidence of CKDu found in other tropical climates may have similar geological origins.