2016/09/07 by Patrick G. Dean, Aleksandra Kukla, Mark D. Stegall +2 · 1 citation
Medicine · Social Sciences · #Clinical trial #Computer science #Diabetes mellitus #Disease #European and International Law Studies #Glycemic #Intensive care medicine #Internal medicine #Kidney transplantation #Liver transplantation #Medicine #Organ Transplantation Techniques and Outcomes #Organ and Tissue Transplantation Research #Pancreas #Pancreas transplantation #Renal Transplantation Outcomes and Treatments #Transplantation #United Network for Organ Sharing
paper · doi:10.1136/bmj.j1321
published in BMJ 357, j1321
openalex created_date 2016/06/24 · openalex publication_date 2016/09/07 · openalex updated_date 2026/06/24
The treatment of patients with diabetes mellitus (DM) presents many challenges to care providers and represents a major proportion of healthcare expenditure worldwide. Successful pancreas transplantation provides durable glycemic control and improves survival for patients with diabetes. Progress in the field has mainly been based on large single center studies and the cumulative analyses of registry data from the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry. This review focuses on the outcomes of pancreas transplantation for patients with and without end stage renal disease. It describes the current state of pancreas transplantation, gaps in knowledge, and future studies needed to enable more patients to benefit from this treatment. A common theme that emerges is the need for multicenter randomized trials in pancreas transplantation to define clearly the efficacy, risks, and long term benefits.