Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus

2007/08/30 by Jin Ye · 134 citations
Medicine · #Hepatitis C virus research #Liver Disease Diagnosis and Treatment #HIV/AIDS drug development and treatment #Hepatitis C virus #Viral life cycle #Virology #Viral replication #Virus #Host (biology) #Flaviviridae #Hepatitis C #Hepacivirus #Biology #Cholesterol #Lipid metabolism #Genetics #Biochemistry

paper · pdf · doi:10.1371/journal.ppat.0030108

published in PLoS Pathogens 3(8), e108 (Public Library of Science)

openalex publication_date 2007/08/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Hepatitis C virus (HCV), a single-stranded positive-sense RNA virus of the Flaviviridae family, infects more than 170 million people worldwide and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral life cycle depends on cholesterol metabolism in host cells. This review summarizes the cholesterol metabolic pathways that are required for the replication, secretion, and entry of HCV. The potential application of drugs that alter host cholesterol metabolism in treating HCV infection is also discussed.

Citations

• Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
• Different anti-HCV profiles of statins and their potential for combination therapy with interferon

Cited by

• Apolipoprotein B [wikipedia]
• Apolipoprotein E [wikipedia]

Related

• Hepatitis C Virus (HCV)–Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design
• Cell surface expression of LDL receptor in chronic hepatitis C: correlation with viral load
• Different anti-HCV profiles of statins and their potential for combination therapy with interferon
• Plasma Lipid Metabolites Differentiate Metabolic From Viral Chronic Liver Disease
• Global Elimination of Hepatitis C Virus