2015/09/01 by Ilya A. Rybak, Kimberly J. Dougherty, Natalia A. Shevtsova · 2 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · Medicine · #Zebrafish Biomedical Research Applications #Neurogenesis and neuroplasticity mechanisms #Axon Guidance and Neuronal Signaling #Central pattern generator #Neuroscience #Biological neural network #Spinal cord #Biology #CpG site #Interneuron #Inhibitory postsynaptic potential #Rhythm #Gene #Medicine #Genetics
paper · pdf · doi:10.1523/eneuro.0069-15.2015
openalex publication_date 2015/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
The organization of neural circuits that form the locomotor central pattern generator (CPG) and provide flexor-extensor and left-right coordination of neuronal activity remains largely unknown. However, significant progress has been made in the molecular/genetic identification of several types of spinal interneurons, including V0 (V0D and V0V subtypes), V1, V2a, V2b, V3, and Shox2, among others. The possible functional roles of these interneurons can be suggested from changes in the locomotor pattern generated in mutant mice lacking particular neuron types. Computational modeling of spinal circuits may complement these studies by bringing together data from different experimental studies and proposing the possible connectivity of these interneurons that may define rhythm generation, flexor-extensor interactions on each side of the cord, and commissural interactions between left and right circuits. This review focuses on the analysis of potential architectures of spinal circuits that can reproduce recent results and suggest common explanations for a series of experimental data on genetically identified spinal interneurons, including the consequences of their genetic ablation, and provides important insights into the organization of the spinal CPG and neural control of locomotion.