1974/07/12 by Donald H. Perkel, Brian Mulloney · 4 citations
Neuroscience · Physics and Astronomy · Chemistry · #Neural dynamics and brain function #stochastic dynamics and bifurcation #Chaos control and synchronization #Tonic (physiology) #Inhibitory postsynaptic potential #Neuroscience #Excitatory postsynaptic potential #Physics #Biophysics #Chemistry #Biology #Biological system
paper · doi:10.1126/science.185.4146.181
openalex publication_date 1974/07/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
Pairs of neurons which inhibit each other can produce regular alternating bursts of impulses if they also exhibit postinhibitory rebound (PIR). Computer studies show that stable patterns occur spontaneously in systems of pacemaker neurons with PIR, and can be triggered in systems of nonpacemakers without requiring tonic excitation. The repetition rates of these patterns are determined largely by the PIR parameters. The patterns resist perturbation by phasic synaptic inputs, but can be modulated or turned off by tonic inputs. One pair of PIR neurons can be entrained by another pair with a different repetition rate to produce more complex firing patterns.