2017/04/05 by Daisuke Kohno · 28 citations
Chemistry · Medicine · Neuroscience · Nursing · #Biochemical Analysis and Sensing Techniques #Biology #Carbohydrate metabolism #Cell biology #Chemistry #Endocrinology #Energy homeostasis #Glucose homeostasis #Homeostasis #Hypothalamus #Insulin #Insulin resistance #Internal medicine #Medicine #Neuroscience #Nutrient sensing #Olfactory and Sensory Function Studies #Receptor #Regulation of Appetite and Obesity #Signal transduction #Taste #Taste receptor
paper · doi:10.1007/s12576-017-0535-y
published in The Journal of Physiological Sciences 67(4), 459-465 (BioMed Central)
openalex publication_date 2017/04/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
The hypothalamic feeding center plays an important role in energy homeostasis. The feeding center senses the systemic energy status by detecting hormone and nutrient levels for homeostatic regulation, resulting in the control of food intake, heat production, and glucose production and uptake. The concentration of glucose is sensed by two types of glucose-sensing neurons in the feeding center: glucose-excited neurons and glucose-inhibited neurons. Previous studies have mainly focused on glucose metabolism as the mechanism underlying glucose sensing. Recent studies have indicated that receptor-mediated pathways also play a role in glucose sensing. This review describes sweet taste receptors in the hypothalamus and explores the role of sweet taste receptors in energy homeostasis.