2005/10/26 by P. Pibarot, J G Dumesnil · 3 citations
Engineering · Medicine · #Aortic valve #Blood pressure #Cardiac Valve Diseases and Treatments #Cardiac pacing and defibrillation studies #Cardiology #Hemodynamics #Internal medicine #Left ventricular hypertrophy #Medicine #Muscle activation and electromyography studies #Muscle hypertrophy #Prosthesis #Surgery
paper · pdf · doi:10.1136/hrt.2005.067363
openalex publication_date 2005/10/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/16
Prosthesis-patient mismatch (PPM) is present when the effective orifice area of the inserted prosthetic valve is too small in relation to body size. Its main haemodynamic consequence is to generate higher than expected gradients through normally functioning prosthetic valves. This review updates the present knowledge about the impact of PPM on clinical outcomes. PPM is common (20-70% of aortic valve replacements) and has been shown to be associated with worse haemodynamic function, less regression of left ventricular hypertrophy, more cardiac events, and lower survival. Moreover, as opposed to most other risk factors, PPM can largely be prevented by using a prospective strategy at the time of operation.