1996/06/01 by Russell W. Anderson · 2 citations
Medicine · Immunology and Microbiology · #Monoclonal and Polyclonal Antibodies Research #T-cell and B-cell Immunology #Galectins and Cancer Biology #Antibody #Biology #Repertoire #Population #Evolutionary biology #Function (biology) #Affinity maturation #Instinct #Genetics #Demography
paper · doi:10.1038/icb.1996.50
openalex publication_date 1996/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
It is shown how Ig specificities, randomly generated in conventional B cells, come to be expressed in the genetically-determinate B1 population. Thus the adaptive antibody population facilitates the evolution of the natural antibody repertoire, in accordance with the Baldwin effect in the evolution of instinct. The evolution of these two populations is discussed under both the 'proximal usage' and 'preferential expression' hypotheses of biased Ig gene segment usage. This process is independent of theories of B1 function.