2015/05/18 by Rima E. Mohamed, Mohammed O. Gadour, Ishag Adam · 1 citation
Agricultural and Biological Sciences · Medicine · Chemistry · #Polysaccharides Composition and Applications #Diabetes, Cardiovascular Risks, and Lipoproteins #Natural Antidiabetic Agents Studies #Hyperlipidemia #Triglyceride #Atorvastatin #Medicine #Blood lipids #Arabic #Significant difference #Internal medicine #Lipid profile #Cholesterol #Gum arabic #Low-density lipoprotein #Traditional medicine #Gastroenterology #Endocrinology #Food science #Diabetes mellitus #Chemistry
paper · pdf · doi:10.3389/fphys.2015.00160
openalex publication_date 2015/05/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Hyperlipidemia especially low density lipoprotein cholesterol (LDL-C) is a major risk factor for developing ischemic heart disease. Soluble dietary fiber has lipid lowering characteristics. Gum Arabic (GA) is 95% soluble fiber calculated on dry bases. The beneficial effect of GA on lipid profile needs further verification. A case-control study was conducted at Omdurman Hospital, Sudan to assess the effect of G A on serum lipids in patients with hyperlipidemia. Cases received a 20 mg tablet of atorvastatin /day plus 30 mg of GA for 4 weeks while the controls received atorvastatin only. Levels of lipids in serum were assessed according to conventional methods before and 1 month after the trial. There is no significant difference in the basic characteristics between the study and the control groups (55 patients in each arm of the study). While there was no significant difference in the levels of HDL, there was a significant reduction of the total cholesterol (25.9 vs. 7.8%, P < 0.001), triglyceride (38.2 vs. 2.9%, P < 0.001), and LDL (30.8 vs. 8.1%, P < 0.001) before and after the intervention in the study compared to the controls groups.