2017/03/03 by Arash Alizad Banaei, Jean-Christophe Loiseau, Iman Lashgari +1 · 21 citations
Chemical Engineering · Engineering · Medicine · Neuroscience · Physics and Astronomy · Psychology · #Blood properties and coagulation #Composite material #Flow (mathematics) #Lattice Boltzmann Simulation Studies #Materials science #Mechanics #Neuroscience #Nucleus #Physics #Psychology #Rheology and Fluid Dynamics Studies #Shear (geology) #Shear flow #Statistical physics #physics.comp-ph #physics.flu-dyn
paper · pdf · open access · doi:10.1080/17797179.2017.1294828
published in European Journal of Computational Mechanics 26(1-2), 131-153 (Taylor & Francis)
openalex publication_date 2017/03/03 · arxiv created 2017/05/25 · arxiv updated 2017/05/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
The shear-induced deformation of a capsule with a stiff nucleus, a model of eukaryotic cells, is studied numerically. The membrane of the cell and of its nucleus are modelled as a thin elastic material obeying a Neo-Hookean constitutive law. The fluid–structure coupling is obtained using an immersed boundary method. The variations induced by the presence of the nucleus on the cell deformation are investigated when varying the viscosity ratio between the inner and outer fluids, the membrane elasticity and its bending stiffness. The deformation of the eukaryotic cell is smaller than that of the prokaryotic one. The reduction in deformation increases for larger values of the capillary number. The eukaryotic cell remains thicker in its middle part compared to the prokaryotic one, thus making it less flexible to pass through narrow capillaries. For a viscosity ratio of 5, the deformation of the cell is smaller than in the case of uniform viscosity. In addition, for non-zero bending stiffness of the membrane, the deformation decreases and the shape is closer to an ellipsoid. Finally, we compare the results obtained modelling the nucleus as an inner stiffer membrane with those obtained using a rigid particle.