Factors Affecting Wound Healing

2010/02/05 by S. Guo, Shuzhen Guo, L.A. DiPietro +1 · 5,673 citations
Health Professions · Medicine · #Bioinformatics #Biology #Diabetic Foot Ulcer Assessment and Management #Hemostasis #Immunology #Inflammation #Intensive care medicine #Medicine #Pressure Ulcer Prevention and Management #Surgery #Wound Healing and Treatments #Wound healing

paper · open access · doi:10.1177/0022034509359125

published in Journal of Dental Research 89(3), 219-229 (SAGE Publishing)

openalex publication_date 2010/02/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05

Abstract

Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutaneous wound healing and the potential cellular and/or molecular mechanisms involved. The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition. A better understanding of the influence of these factors on repair may lead to therapeutics that improve wound healing and resolve impaired wounds.

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