Sensitivity of Salivary Glands to Radiation: from Animal Models to Therapies

2009/09/25 by O. Grundmann, Oliver Grundmann, G.C. Mitchell +3 · 26 citations
Medicine · #Effects of Radiation Exposure #Head and Neck Cancer Studies #Salivary Gland Disorders and Functions

paper · doi:10.1177/0022034509343143

Abstract

Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.

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