Mechanisms of Tooth Eruption and Orthodontic Tooth Movement

2008/05/01 by G.E. Wise, G.J. King, Gregory J. King · 27 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #dental development and anomalies #Bone Metabolism and Diseases #Bone and Dental Protein Studies

paper · doi:10.1177/154405910808700509

Abstract

Teeth move through alveolar bone, whether through the normal process of tooth eruption or by strains generated by orthodontic appliances. Both eruption and orthodontics accomplish this feat through similar fundamental biological processes, osteoclastogenesis and osteogenesis, but there are differences that make their mechanisms unique. A better appreciation of the molecular and cellular events that regulate osteoclastogenesis and osteogenesis in eruption and orthodontics is not only central to our understanding of how these processes occur, but also is needed for ultimate development of the means to control them. Possible future studies in these areas are also discussed, with particular emphasis on translation of fundamental knowledge to improve dental treatments.

Cited by

• Mechanism of action and morphologic changes in the alveolar bone in response to selective alveolar decortication–facilitated tooth movement
• PTH/PTHrP in controlled release hydrogel enhances orthodontic tooth movement by regulating periodontal bone remodaling
• Cellular and molecular basis of tooth eruption. [europepmc]
• Role of Wnt signaling in the biology of the periodontium. [europepmc]
• Electroporation optimization to deliver plasmid DNA into dental follicle cells. [europepmc]
• TNF-alpha upregulates expression of BMP-2 and BMP-3 genes in the rat dental follicle--implications for tooth eruption. [europepmc]
• A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots. [europepmc]
• The etiology of eruption disorders - further evidence of a 'genetic paradigm' [europepmc]
• Requirement of alveolar bone formation for eruption of rat molars. [europepmc]
• Mechanical stretch increases the proliferation while inhibiting the osteogenic differentiation in dental pulp stem cells. [europepmc]
• Tooth eruption results from bone remodelling driven by bite forces sensed by soft tissue dental follicles: a finite element analysis. [europepmc]
• Role of ortho-retronasal olfaction in mammalian cortical evolution. [europepmc]
• Multiple essential MT1-MMP functions in tooth root formation, dentinogenesis, and tooth eruption. [europepmc]
• Periodontal Ligament Stem Cells in the Periodontitis Microenvironment Are Sensitive to Static Mechanical Strain. [europepmc]
• The effectiveness of vibrational stimulus to accelerate orthodontic tooth movement: a systematic review. [europepmc]
• Orthodontic tooth movement: The biology and clinical implications. [europepmc]
• Periodontal cell mechanotransduction. [europepmc]
• Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth Movement. [europepmc]
• Shedding new light on the mysteries of tooth eruption. [europepmc]
• External apical root resorption in non-extraction cases after clear aligner therapy or fixed orthodontic treatment. [europepmc]
• High-throughput sequencing analysis of the expression profile of microRNAs and target genes in mechanical force-induced osteoblastic/cementoblastic differentiation of human periodontal ligament cells. [europepmc]
• Mesenchymal Progenitor Regulation of Tooth Eruption: A View from PTHrP. [europepmc]
• Interleukin-1β Induced Matrix Metalloproteinase Expression in Human Periodontal Ligament-Derived Mesenchymal Stromal Cells under In Vitro Simulated Static Orthodontic Forces. [europepmc]
• Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade. [europepmc]
• Function of Dental Follicle Progenitor/Stem Cells and Their Potential in Regenerative Medicine: From Mechanisms to Applications. [europepmc]
• The Role of Wnt Signaling in Postnatal Tooth Root Development. [europepmc]
• Osteoimmunology in Periodontitis and Orthodontic Tooth Movement. [europepmc]

Related

• Current knowledge of tooth development: patterning and mineralization of the murine dentition
• Role of osteoclasts in oral homeostasis and jawbone diseases
• Inflammatory Response Mechanisms of the Dentine–Pulp Complex and the Periapical Tissues
• Microanatomical changes and biomolecular expression at the PDL‐entheses during experimental tooth movement
• Local and Chronic Application of PTH Accelerates Tooth Movement in Rats