2016/10/01 by Patrick Varilly, Adam P. Willard, Julius B. Kirkegaard +2
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · Physics and Astronomy · #Amphiphile #Biology #Biophysics #Chemical physics #Chemistry #Context (archaeology) #Copolymer #Hydrophobic effect #Material Dynamics and Properties #Materials science #Monte Carlo method #Nanotechnology #Organic chemistry #Pickering emulsions and particle stabilization #Polymer #Surfactants and Colloidal Systems #cond-mat.soft #physics.bio-ph #q-bio.BM
paper · pdf · doi:10.1063/1.4977932
arxiv created 2016/10/01 · openalex publication_date 2017/04/07 · arxiv updated 2017/04/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Aggregation of amphiphiles through the action of hydrophobic interactions is a common feature in soft condensed matter systems and is of particular importance in the context of biophysics as it underlies both the generation of functional biological machinery as well as the formation of pathological misassembled states of proteins. Here we explore the aggregation behaviour of amphiphilic polymers using lattice Monte Carlo calculations and show that the distribution of hydrophobic residues within the polymer sequence determines the facility with which dry/wet interfaces can be created and that such interfaces drive the aggregation process.