2017/04/17 by Lu Gao, Jun Zhou, Le‐Yu Zhu +7 · 1 citation
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · #Phytochemistry and Biological Activities #Electron Spin Resonance Studies #Natural product bioactivities and synthesis #Diterpene #HeLa #Chemistry #Cytotoxic T cell #Stereochemistry #HL60 #Two-dimensional nuclear magnetic resonance spectroscopy #Cytotoxicity #Biochemistry #Cell #In vitro
paper · doi:10.1002/cbdv.201700071
openalex publication_date 2017/04/17 · openalex created_date 2017/04/28 · openalex updated_date 2026/06/06
Four new diterpene glucosides, namely perovskiaditerpenosides A - D (1 - 4), were isolated from the BuOH extract of Perovskia atriplicifolia. Their structures were well elucidated by chemical methods and comprehensive spectroscopic analyses including MS, IR, and NMR (1D and 2D). The newly isolated compounds were screened for their cytotoxic activity against HepG2, NB4, HeLa, K562, MCF7, PC3, and HL60. The obtained results indicated that the new compounds possessed considerable cytotoxic activity.