2014/01/01 by Stefan Kurtenbach, Sarah Kurtenbach, Georg Zoidl · 1 citation
Biochemistry, Genetics and Molecular Biology · Neuroscience · Engineering · #Connexins and lens biology #Nicotinic Acetylcholine Receptors Study #Heat shock proteins research #Gap junction #Blueprint #Function (biology) #Neuroscience #Connexin #Biology #Computational biology #Computer science #Cell biology #Engineering
paper · pdf · doi:10.3389/fphys.2014.00082
openalex publication_date 2014/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Gap junction communication (GJC) mediated by connexins is critical for heart function. To gain insight into the causal relationship of molecular mechanisms of disease pathology, it is important to understand which mechanisms contribute to impairment of gap junctional communication. Here, we present an update on the known modulators of connexins, including various interaction partners, kinases, and signaling cascades. This gap junction network (GJN) can serve as a blueprint for data mining approaches exploring the growing number of publicly available data sets from experimental and clinical studies.