2014/12/15 by Yiwu Zhao, Fuyong Ni, Yaling Song +4 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · Chemistry · #Sesquiterpenes and Asteraceae Studies #Medicinal plant effects and applications #Herbal Medicine Research Studies #Quinic acid #Artemisia annua #Chemical constituents #Scopoletin #Chemistry #Silica gel #Chromatography #High-performance liquid chromatography #Column chromatography #Artemisia #Organic chemistry #Botany #Biology #Artemisinin
paper · doi:10.4268/cjcmm20142423
openalex publication_date 2014/12/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
OBJECTIVE: To investigate the chemical constituents of dried whole plants of Artemisia annua. METHOD: The chemical constituents were isolated by repeated silica gel chromatography, medium pressure column chromatography, and semi-preparative HPLC, and their structures were elucidated by spectroscopic analyses and comparison of NMR data with those reported in literature. RESULT: 15 compounds were isolated and identified to be 5-O-[(E)-Caffeoyl] quinic acid(l), 1,3-di-O-caffeoylquinic acid(2), 4 5-di-O-caffeoylquinic acid(3), 3, 5-di-O-caffeoylquinic acid (4), 3, 4-di-O-caffeoylquinic acid (5), methyl-3,4-di-O-caffeoylquinic acid(6), methyl-3,5-di-O-caffeoylquinic acid(7), 3,6'-O-diferuloylsucrose(8), 5'-β-D-glucopyranosyloxyjasmonic acid(9), Scopoletin(10), scoparone (11), 4-O-β-D-glucopyranosyl-2-hydroxyl-6-methoxyacetophenone (12), chrysosplenol D (13), casticin (14), chrysosplenetin(15). CONCLUSION: Compounds 2, 6, 8 and 9 are obtained from the Artemisia genus for the first time. Compounds 7 and 15 are obtained from this plant for the first time.